PDF Proteome Research: Concepts, Technology and Application

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It combines powerful separation and analytical technology with advanced informatics to understand the function of proteins in the cell and in the body. This book provides a clear conceptual description of each facet of proteomics, describes recent advances in technology and thinking in each area, and provides details of how these have been applied to a variety of biological problems. It is written by expert practitioners in the field, from industry, research institutions, and the clinic. It provides junior and experienced researchers with an invaluable proteomic reference, and gives fascinating glimpses of the future of this dynamic field.

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The power of proteomics

Go to British Wildlife. Conservation Land Management. Go to Conservation Land Management. Publisher: Springer Nature. Click to have a closer look. Select version.

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About this book Customer reviews Related titles. Electrophoresis ;20 18 An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. Am Soc Mass Spectrom ;5 An introduction to quadrupoletime- of-flight mass spectrometry.

J Mass Spectrom ;36 8 The non-linear resonance ion trap. Part 2. A general theoretical analysis. The Orbitrap: a new mass spectrometer. J Mass Spectrom. Walther TC, Mann M. Mass spectrometry-based proteomics in cell biology. J Cell Biol.

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Anal Chem.

Customer Reviews

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Workflow comparison for label-free, quantitative secretome proteomics for cancer biomarker discovery: method evaluation, differential analysis, and verification in serum. Comparison of label-free methods for quantifying human proteins by shotgun proteomics.

Two-dimensional gel electrophoresis. Mass spectrometry-based proteomics in biomedical research: emerging technologies and future strategies. Expert Rev Mol Med. Phosphoproteomics identifies oncogenic Ras signaling targets and their involvement in lung adenocarcinomas. PLoS One. Lung cancer serum biomarker discovery using glycoprotein capture and liquid chromatography mass spectrometry. Mass spectrometry-based clinical proteomics: head-and-neck cancer biomarkers and drug-targets discovery. Proteomic serum biomarkers and their potential application in cancer screening programs.

Findeisen P, Neumaier M. Mass spectrometry based proteomics profiling as diagnostic tool in oncology: current status and future perspective. Clin Chem Lab Med.

Fung ET. Clin Chem. Zhang Z, Chan DW. The road from discovery to clinical diagnostics: lessons learned from the first FDA-cleared in vitro diagnostic multivariate index assay of proteomic biomarkers. Cancer Epidemiol Biomarkers Prev. Targeted proteomic strategy for clinical biomarker discovery. Mol Oncol. Study of urinary proteomes in Anderson-Fabry disease. Ren Fail. Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers. Galectin-3 is a candidate biomarker for amyotrophic lateral sclerosis: discovery by a proteomics approach. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease.

Nat Rev Neurol. Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt-Jakob disease. Diagnostic cerebrospinal fluid biomarkers for Parkinsons disease: a pathogenetically based approach. Neurobiol Dis. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther.

Proteomic analysis of the tear film in patients with keratoconus.

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Mol Vis ; Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry. Breast Cancer Res Treat. Dawes C. Salivary flow patterns and the health of hard and soft oral tissues. J Am Dent Assoc. In vitro remineralisation of eroded enamel lesions by saliva.

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J Dent. Tabak LA. In defense of the oral cavity: the protective role of the salivary secretions. Pediatr Dent. Relationship between salivary flow rate and clinical symptoms and behaviours in patients with dry mouth. J Oral Rehabil. Aminotransferases and lactate dehydrogenase in saliva of diabetic patients. J Oral Pathol Med. Complexity of the human whole saliva proteome.

J Physiol Biochem. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis of human parotid salivary proteins. Salivary proteins in rheumatoid arthritis and Sjogrens syndrome: one-dimensional and two-dimensional electrophoretic studies. HSP is present in human saliva. Med Sci Monit. Comparison of electrokinetics-based multidimensional separations coupled with electrospray ionization-tandem mass spectrometry for characterization of human salivary proteins.

Mapping of proteins in human saliva using two-dimensional gel electrophoresis and peptide mass fingerprinting. Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry. Cancer Genomics Proteomics. Salivary proteomics for oral cancer biomarker discovery.

Clin Cancer Res.