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Basic Chemistry of Nitric Oxide and Related Nitrogen Oxides | SpringerLink

Related Meeting. Conference Program. Sunday pm - pm Arrival and Check-in. Mattias Carlstrom Karolinska Institutet, Sweden. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Elsevier - Nitric Oxide Journal. Conference Links.

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Registration Fees Additional Fee Info. Contact Us Call Us: It plays key roles as a signaling molecule in a number of mammalian physiological and pathophysiological processes. The reactions of nitric oxide with transition metals are of great chemical interest and also key in understanding diverse biological processes. The overlapping areas to be investigated in this project are:. Interactions of metal-nitrosyls with potential biological targets viz. Cytotoxicity and mechanism of actions will be studied to elucidate their efficiency as potential therapeutic agents.

Ordinances Press Forms Office Orders. Overview Weather Information. Press Releases Media Coverage. On the pH-dependent yield of hydroxyl radical products from peroxynitrite. Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite. Arch Biochem Biophys ; — Oxidative chemistry of peroxynitrite. Methods Enzymol ; — Huie RE, Padmaja S. The reaction of NO with superoxide. Goldstein S, Czapski G.

Pulse radiolysis for investigation of nitric oxide-related reactions. In: Packer L, ed.

Dr. Louis Ignarro - Nitric Oxide and Disease Prevention

Oxygen Radicals in Biological systems, Pt C. Methods Enzymol Academic Press, ; — Reactivity of nitric oxide with simple short-lived radicals in aqueous solutions. Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide-mediated killing. Koppenol WH. Thermodynamic considerations on the formation of reactive species from, hypochlorite, superoxide and nitrogen monoxide. Could nitrosyl chloride be produced by neutrophils and macrophages? FEBS Lett ; —8. Aqueous nitrite ion determination by selective reduction and gas phase nitric oxide chemiluminescence.


  1. Pharmacological nitric oxide research | Karolinska Institutet.
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Anal Chem ; — Highlights of current research involving superoxide and perhydroxyl radicals in aqueous solutions. Cytoprotective function of nitric oxide: in-activation of superoxide radicals produced by human leukocytes. Peroxynitrite formation from macrophage-derived nitric oxide. Nitric oxide and oxygen radicals: a question of balance. Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. Biochem J ; — Simultaneous generation of nitric oxide and superoxide by inflammatory cells in rats.

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase.


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  • Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils. Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania Major. Eur J Immunol ; — The formation of peroxynitrite in vivo from nitric oxide and superoxide.

    Chem-Biol Interac ; — Garthwaite J, Boulton CL. Nitric oxide signaling in the central nervous system. Annu Rev Physiol ; — Kinetic modelling of the nitric oxide gradient generated in vitro by adherent cells expressing inducible nitric oxide synthase.

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    Padmaja S, Huie RE. The reaction of nitric oxide with organic peroxyl radicals. Cueto R, Pryor WA. Cigarette smoke chemistry: conversion of nitric oxide to nitrogen dioxide and reactions of nitrogen oxides with other smoke components as studied by Fourier transform infrared spectroscopy.

    Vibrational Spectroscopy ; — Trapping of nitric oxide by nitronyl nitroxides: an electron spin resonance investigation. Therapeutic effects of imidazolineoxyl N -oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Lagercrantz C. Peroxynitrite-mediated oxidation of albumin to the protein-thiyl free radical. Inhibition of ribonucleotide reductase by nitric oxide derived from thionitrites: reversible modifications of both subunits.

    Reactions of nitric oxide with phenolic antioxidants and phenoxyl radicals. J Org Chem ; — Nitric oxide rapidly scavenges tyrosine and tryptophan radicals. Electrophilic behaviour of the coordinated nitrosyl cation.

    Biological functions of nitric oxide

    J Chem Soc Comm ; — Principles of structure, bonding, and reactivity for metal nitrosyl complexes. Coord Chem Reviews ; — Huheey JE. Inorganic Chemistry. Harper and Row Pub, , — Resonance Raman investigation of nitric oxide bonding in iron porphyrins: detection of the Fe-NO stretching vibration.

    Nitric Oxide

    Pombeiro AJL. Coordination chemistry of small unsaturated- N molecules at electron-rich mononuclear centers: cyanamide, organonitriles, nitric oxide and related species. New J Chem ; — O-functionalization chemistry. New nitric oxide-releasing zwitterions derived from polyamines. Complexes of nitric oxide with nucleophiles as agents for the controlled biological release of nitric oxide: antiplatelets effect.

    Thrombosis and Haemostasis ; — Morley D, Keefer LK. J Cardiovasc Pharmacol ; S3-S9. J Cardiovasc Pharmacol ; — Protection of glutathione against the antiproliferative effects of nitric oxide: dependence on kinetics of NO release.